Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.
Simon RothwellGabriela Arredondo Hector ChinoyJanine A LambFrederick W MillerLisa G RiderLucy R WedderburnNeil J McHughAndrew Lee MammenZoe E BetteridgeSarah L TansleyJohn David BowesJiří VencovskýClaire T DeakinKatalin DankóLimaye VidyaAlbert Selva-O'CallaghanLauren M PachmanAnn M ReedØyvind MolbergOlivier BenvenistePernille R MathiesenTimothy R D J RadstakeAndrea DoriaJan de BleeckerAnnette T LeeMichael G HannaPedro M MachadoWilliam E OllierPeter K GregersenLeonid PadyukovTerrance P O'HanlonRobert G CooperIngrid E Lundbergnull nullPublished in: Annals of the rheumatic diseases (2019)
These findings provide new insights regarding the functional consequences of genetic polymorphisms within the MHC. As autoantibodies in IIM correlate with specific clinical features of disease, understanding genetic risk underlying development of autoantibody profiles has implications for future research.