Synthesized nanoliposome-encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium-induced toxicity.
Vahideh HaeriEhsan KarimiEhsan OskoueianPublished in: Biotechnology and applied biochemistry (2022)
In the present research, we encapsulated a flavonoid called kaempferol into nanoliposomal structures and the health-promoting effects of synthesized nanoliposome-loaded kaempferol (NLK) were evaluated in mice challenged by cadmium-induced . The NLK characteristics, such as size, zeta potential, and polydispersity index, were 218.4 nm, -28.55 mV, and 0.29, respectively. The in vivo experiment revealed that the mice receiving water containing cadmium (2 mg/kg body weight/day) showed significant (p < 0.05) weight loss, an increase in liver enzyme activities, and hepatic oxidative stress. Dietary supplementation with NLK at concentrations of 2.5 and 5 mg/kg mice body weight notably (p < 0.05) improved the body weight, liver enzyme activities, hepatic oxidative stress, and antioxidant potential of the liver. Our findings elucidated that NLK could alleviate the toxicity of cadmium in mice challenged by cadmium-induced toxicity.
Keyphrases
- body weight
- oxidative stress
- diabetic rats
- high fat diet induced
- gene expression
- heavy metals
- healthcare
- high glucose
- weight loss
- public health
- mental health
- dna methylation
- drug delivery
- type diabetes
- drug induced
- induced apoptosis
- ischemia reperfusion injury
- photodynamic therapy
- risk assessment
- endothelial cells
- health information
- skeletal muscle
- mass spectrometry
- anti inflammatory
- wound healing