CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy.

Hongfei WangYixuan SunXiuman ZhouChunxia ChenLing JiaoWanqiong LiShanshan GouYanying LiJiangfeng DuGuanyu ChenWenjie ZhaiYahong WuYuanming QiYan-Feng Gao

Published in: Journal for immunotherapy of cancer (2021)

In summary, these results demonstrated that CD47/SIRPα blocking peptides, pep-20 and its derivate, could serve as promising candidates to promote macrophages-mediated phagocytosis and immune response in cancer immunotherapy.

Keyphrases

immune response
nk cells
dendritic cells
radiation therapy
radiation induced