Circulating Tumor DNA Analysis: Clinical Implications for Colorectal Cancer Patients. A Systematic Review.
Sander BachNina R SluiterJamie J BeaganJoost M MekkeJohannes C F KetNicole C T van GriekenRenske D M SteenbergenBauke YlstraGeert KazemierJurriaan B TuynmanPublished in: JNCI cancer spectrum (2019)
This comprehensive overview of ctDNA candidate markers demonstrates SEPT9 methylation analysis to be promising for CRC detection, and KRAS mutation analysis could assist in prognostication and monitoring. Prospective evaluation of marker panels in clinical decision making should bring ctDNA analysis into practice.