Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy.

Antonella AntenoraDario BruzzeseMaria LietoAlessandro RocaMaria Teresa FlorioSilvio PelusoFrancesco SaccàGiuseppe De MicheleFilippo Maria SantorelliAlessandro Filla

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2018)

One hundred-eighteen spinocerebellar ataxia type 2 patients from 35 distinct families personally observed between 1973 and 2016 were retrospectively reviewed. The time point of data collection was 1 January 2017. Thirty-one patients were confined to wheelchair. The median time to wheelchair was 21 years (95% CI, 17.5-24.6). Thirty-seven patients were deceased. The median time to death was 25 years (95% CI, 22.9-27.1). CAG repeat number and ataxia score at first visit influenced the time to wheelchair and death.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
prognostic factors
early onset
machine learning
patient reported outcomes
data analysis
kidney transplantation