Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma.

Marie-Pier TremblayVictoria E S ArmeroAndréa AllaireSimon BoudreaultCamille Martenon-BrodeurMathieu DurandElvy LapointePhilippe ThibaultMaude Tremblay-LétourneauJean-Pierre PerreaultMichelle S ScottMartin Bisaillon

Published in: BMC genomics (2016)

This study provides the first comprehensive portrait of global changes in the RNA splicing signatures that occur in hepatocellular carcinoma. Moreover, these data allowed us to identify unique signatures of genes for which AS is misregulated in the different types of HCC.

Keyphrases

genome wide
electronic health record
single cell
nucleic acid
big data
gene expression
machine learning
data analysis