Iron deficiency impacts prognosis but less exercise capacity in heart failure with preserved ejection fraction.
Arantxa Barandiarán AizpuruaSandra Sanders-van WijkHans-Peter Brunner-La RoccaMichiel T H M HenkensJerremy WeertsMireille H A SpanjersChristian KnackstedtVanessa P M van EmpelPublished in: ESC heart failure (2021)
Heart failure with preserved ejection fraction patients with ID have a worse prognosis and impaired exercise capacity compared with those without ID. However, although a trend was observed, after multivariable correction ID was no longer significantly associated with a reduced exercise capacity. This reflects that impaired exercise capacity in HFpEF is complex and seems multifactorial. Interestingly, pulmonary hypertension was an independent predictor of both ID and exercise capacity.