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Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis.

Lina-Marcela Diaz-GalloDaniel RamsköldKlementy ShchetynskyLasse FolkersenKarine CheminBoel BrynedalSteffen UebeYukinori OkadaLars AlfredssonLars KlareskogLeonid Padyukov
Published in: Annals of the rheumatic diseases (2018)
Our data demonstrate that there are massive genetic interactions between the HLA-DRB1 SE alleles and non-HLA genetic variants in ACPA-positive RA.
Keyphrases
  • rheumatoid arthritis
  • disease activity
  • copy number
  • ankylosing spondylitis
  • electronic health record
  • gene expression
  • big data
  • systemic lupus erythematosus
  • machine learning
  • dna methylation
  • systemic sclerosis