Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis.
Alireza AmanollahiTannaz BabeveynezhadMohsen SedighiShahin ShadniaSadaf AkbariMahbobeh TaheriMahboobeh BesharatpourGoljamal JorjaniElham SalehianKoorosh EtemadYadollah MehrabiPublished in: Scientific reports (2023)
Rhabdomyolysis is a potentially life-threatening condition induced by diverse mechanisms including drugs and toxins. We aimed to investigate the incidence of rhabdomyolysis occurrence in intoxicated patients with psychoactive substances. In this review, three databases (PubMed, Scopus, Web of Science) and search engine (Google Scholar) were searched by various keywords. After the screening of retrieved documents, related data of included studies were extracted and analyzed with weighted mean difference (WMD) in random effect model. The highest incidence of rhabdomyolysis was observed in intoxication with heroin (57.2 [95% CI 22.6-91.8]), amphetamines (30.5 [95% CI 22.6-38.5]), and cocaine (26.6 [95% CI 11.1-42.1]). The pooled effect size for blood urea nitrogen (WMD = 8.78, p = 0.002), creatinine (WMD = 0.44, p < 0.001), and creatinine phosphokinase (WMD = 2590.9, p < 0.001) was high in patients with rhabdomyolysis compared to patients without rhabdomyolysis. Our results showed a high incidence of rhabdomyolysis induced by psychoactive substance intoxication in ICU patients when compared to total wards. Also, the incidence of rhabdomyolysis occurrence was high in ICU patients with heroin and amphetamine intoxication. Therefore, clinicians should anticipate this complication, monitor for rhabdomyolysis, and institute appropriate treatment protocols early in the patient's clinical course.
Keyphrases
- acute kidney injury
- risk factors
- end stage renal disease
- chronic kidney disease
- risk assessment
- ejection fraction
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- public health
- palliative care
- magnetic resonance
- clinical trial
- magnetic resonance imaging
- computed tomography
- mechanical ventilation
- uric acid
- case report
- patient reported
- study protocol
- acute respiratory distress syndrome
- replacement therapy
- case control
- prefrontal cortex