Inhibitory effects of sodium pentosan polysulfate on formation and function of osteoclasts derived from canine bone marrow.
H M Suranji WijekoonEugene C BwalyaJing FangSangho KimKenji HosoyaMasahiro OkumuraPublished in: BMC veterinary research (2018)
Taken together, all the results suggest that NaPPS is a novel inhibitor of RANKL and M-CSF-induced CTK, MMP-9, NFATc1, c-Fos, AP-1 upregulation, OC differentiation and bone resorption which might be a beneficial for treatment of inflammatory joint diseases and other bone diseases associated with excessive bone resorption.
Keyphrases
- bone loss
- bone mineral density
- bone marrow
- soft tissue
- bone regeneration
- mesenchymal stem cells
- transcription factor
- postmenopausal women
- oxidative stress
- cell proliferation
- body composition
- physical activity
- inflammatory response
- immune response
- cell migration
- drug induced
- cerebrospinal fluid
- toll like receptor
- stress induced