Cancer-educated mammary adipose tissue-derived stromal/stem cells in obesity and breast cancer: spatial regulation and function.
Andreas RitterNina-Naomi KreisSusanne RothAlexandra FriemelBabek Kahn SafdarSamira Catharina HoockJulia Maria WildnerRoman AllertFrank LouwenChristine SolbachJuping YuanPublished in: Journal of experimental & clinical cancer research : CR (2023)
This study provides mechanistic insights into how obesity affects the phenotype of bASCs in the TME. Moreover, it highlights the molecular changes inside breast cancer cells upon cell-cell interaction with cancer-educated bASCs.
Keyphrases
- insulin resistance
- stem cells
- papillary thyroid
- adipose tissue
- cell therapy
- metabolic syndrome
- single cell
- weight loss
- breast cancer cells
- type diabetes
- squamous cell
- weight gain
- high fat diet induced
- childhood cancer
- high fat diet
- lymph node metastasis
- bone marrow
- skeletal muscle
- squamous cell carcinoma
- body mass index
- single molecule
- physical activity