Titanium coated with poly(lactic-co-glycolic) acid incorporating simvastatin: Biofunctionalization of dental prosthetic abutments.

Gustavo J S LittumaMariane Beatriz SordiRaissa Borges CurtarelliÁguedo AragonêsAriadne Cristiane Cabral da CruzRicardo S Magini

Published in: Journal of periodontal research (2019)

A slow and controlled release of SIM was achieved, attributed to a diffusional mass transfer mechanism. Moreover, a homogenous coating topography was obtained. Additionally, 0.6% SIM incorporated into PLGA coating improved fibroblasts L929 viability compared to titanium or PLGA. Also, 0.6% SIM incorporated into PLGA promoted cell viability of about 100% for HGFs and approximately 150% for human mesenchymal stem cells. Therefore, this study allows to consider the use of PLGA-coated titanium incorporating SIM as a biofunctionalized abutment for dental implants.

Keyphrases

drug delivery
drug release
mesenchymal stem cells
bone regeneration
endothelial cells
bone marrow
oral health
extracellular matrix
electron transfer