The CXCL13/CXCR5 Immune Axis in Health and Disease-Implications for Intrathecal B Cell Activities in Neuroinflammation.
Christine HarrerFerdinand OttoRichard Friedrich RadlbergerTobias MoserGeorg PilzPeter WipflerAndrea HarrerPublished in: Cells (2022)
The chemokine C-X-C- ligand 13 (CXCL13) is a major B cell chemoattractant to B cell follicles in secondary lymphoid organs (SLO) that proposedly recruits B cells to the cerebrospinal fluid (CSF) during neuroinflammation. CXCR5, the cognate receptor of CXCL13, is expressed on B cells and certain T cell subsets, in particular T follicular helper cells (Tfh cells), enabling them to follow CXCL13 gradients towards B cell follicles for spatial proximity, a prerequisite for productive T cell-B cell interaction. Tfh cells are essential contributors to B cell proliferation, differentiation, and high-affinity antibody synthesis and are required for germinal center formation and maintenance. Circulating Tfh cells (cTfh) have been observed in the peripheral blood and CSF. Furthermore, CXCL13/CXCR5-associated immune activities organize and shape adaptive B cell-related immune responses outside of SLO via the formation of ectopic lymphoid structures in inflamed tissues, including the central nervous system (CNS). This review summarizes the recent advances in our understanding of the CXCL13/CXCR5 immune axis and its role in vaccination, autoimmunity, and infection with a special focus on its relevance for intrathecal B cell activities in inflammatory CNS diseases.
Keyphrases
- induced apoptosis
- cell cycle arrest
- cerebrospinal fluid
- peripheral blood
- immune response
- cell proliferation
- oxidative stress
- endoplasmic reticulum stress
- public health
- gene expression
- blood brain barrier
- dendritic cells
- signaling pathway
- cell cycle
- inflammatory response
- pi k akt
- brain injury
- mass spectrometry
- regulatory t cells
- health information
- heat shock protein
- cognitive impairment
- binding protein