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Dichloromeldrum's Acid (DiCMA): A Practical and Green Amine Dichloroacetylation Reagent.

David M HeardAlastair J J Lennox
Published in: Organic letters (2021)
Dichloromeldrum's acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce α,α-dichloroacetamides, which are important motifs for medicinal chemistry. Products are formed in good to excellent yields with reagent grade solvents, and, as the only byproducts are acetone and CO2, no column chromatography is required. Thus, this reagent is practical, efficient, and green for the dichloroacetylation of primary amines.
Keyphrases
  • ionic liquid
  • liquid chromatography
  • mass spectrometry
  • drinking water
  • high speed
  • tandem mass spectrometry