Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease.

Adrianne F PikeFrancesca LonghenaGaia FaustiniJean-Marc van EikIris GombertMaaike A C HerreboutMona M H E FayedMichele SandreTatiana VaranitaCharlotte E TeunissenJeroen J M HoozemansArianna BellucciRobert VeerhuisLuigi Bubacco

Published in: Journal of neuroinflammation (2022)

efflux-dependent microglial NLRP3 inflammasome activation that contributes to dopaminergic neurodegeneration in PD, and that this reciprocation may account for the specific vulnerability of these neurons to disease pathology.

Keyphrases

nlrp inflammasome
inflammatory response
lipopolysaccharide induced
neuropathic pain
lps induced
spinal cord
climate change
metabolic syndrome