Anion-Responsive Molecules That Exhibit Switching of Two-Photon Optical Properties.

Two-photon-excited fluorescent probes are important for two-photon microscopy for biomedical studies. In contrast to the many examples of probes for cationic species, such as metal ions, there have been fewer reports on the control of two-photon optical properties by anions because in such systems it is difficult to control the associated π-electronic states. This Minireview summarizes anion-responsive molecules that exhibit changes in two-photon optical properties and describes their molecular design and anion-response mechanisms, which are driven by changes in covalent bonds and noncovalent interactions. Results from a recent study of two-photon systems, where geometries and optical properties are modulated by anion binding, are also discussed.