Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model.
Claire C BanielElizabeth G SumiecJacquelyn A HankAmber M BatesAmy K ErbeAlexander A PieperAnna G HoefgesRavi B PatelAlexander L RakhmilevichZachary S MorrisPaul M SondelPublished in: Journal for immunotherapy of cancer (2021)
Intratumoral injection may be a means of overcoming ADA neutralization of therapeutic activity of tumor-reactive mAbs or ICs and may reduce systemic toxicity, which could have significant translational relevance.
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