Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia.
Marco BusnelliStefano ManziniAlice ColomboElsa FranchiFabrizia BonacinaMatteo ChiaraFrancesca ArnaboldiElena DonettiFederico AmbrogiRoberto OleariAntonella LettieriDavid Stephen HornerEugenio ScanzianiGiuseppe Danilo NorataGiulia ChiesaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
HDL deficiency, in the absence of hyperlipidemia, is associated with severe alterations of skin morphology, aortic and coronary atherosclerosis, local and systemic inflammation.
Keyphrases
- high fat diet induced
- coronary artery
- coronary artery disease
- soft tissue
- high fat diet
- cardiovascular disease
- pulmonary artery
- wound healing
- oxidative stress
- aortic valve
- insulin resistance
- aortic stenosis
- left ventricular
- early onset
- type diabetes
- adipose tissue
- metabolic syndrome
- replacement therapy
- skeletal muscle
- pulmonary hypertension
- smoking cessation