Synthesis of Cyclopenta[ b]piperazinones via an Azaoxyallyl Cation.
Boubacar BaldéGuillaume ForceLucile MarinRégis GuillotEmmanuelle SchulzVincent GandonDavid LebœufPublished in: Organic letters (2018)
A new and efficient reaction sequence between 2-furylcarbinols, anilines, and α-haloamides has been developed to afford highly functionalized cyclopenta[ b]piperazinones. This transformation was accomplished through an aza-Piancatelli cyclization/azaoxyallyl cation trapping with a complete control of the diastereoselectivity.