HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.

Guanghui ZhangRuoyue TanSicheng WanRui YangXiaosong HuErhu ZhaoXiangfei DingJingping ZhangBiao LiPing Liang Hong-Juan Cui

Published in: British journal of cancer (2022)

Our results unveil the potential role of HECTD3 in glioblastoma and strongly preconise further investigation and consider HECTD3 as a promising therapeutic marker for glioblastoma treatment.

Keyphrases

small cell lung cancer
dna damage
signaling pathway
epidermal growth factor receptor
dna repair
risk assessment
combination therapy
human health
replacement therapy