Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.

Xiaoting SunXingkang HeYin ZhangKayoko HosakaPatrik AnderssonJing WuJieyu WuXu JingQiqiao DuXiaoli HuiBo DingZiheng GuoAn HongXuan LiuYan WangQing JiRudi BeyaertYunlong YangQi LiYihai Cao

Published in: Gut (2021)

Our work provides novel mechanistic insights into understanding PDAC metastasis by the TAM-CAF interaction and targeting each of these signalling components would provide an attractive and new paradigm for treating pancreatic cancer.

Keyphrases

papillary thyroid
oxidative stress
squamous cell
transforming growth factor
young adults