Anti-inflammatory flavonoid derivatives from the heartwood of Dalbergia odorifera T. Chen.
Ni-Li ZanZi-Han LuXin-Yu WangRong-Ye WangNai-Yun LiangHui-Xia HuoYun-Fang ZhaoYue-Lin SongPeng-Fei TuJiao ZhengJun LiPublished in: Natural product research (2022)
Two pairs of flavonoid enantiomers ( 1a / 1b and 2a / 2b ) together with three known analogues ( 3 - 5 ) were isolated from the heartwood of Dalbergia odorifera T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data. Compound 2 features an unusual 2-methyl-3(2 H )-furanone moiety forming the C-ring of flavonoid, and its putative biosynthetic pathway is also proposed. Compounds 3 ‒ 5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC 50 values of 14.7 ± 0.3 μM, 40.2 ± 1.1 μM, and 3.2 ± 0.1 μM, respectively.
Keyphrases
- nitric oxide
- molecular docking
- anti inflammatory
- induced apoptosis
- high resolution
- cell cycle arrest
- magnetic resonance
- toll like receptor
- inflammatory response
- structure activity relationship
- electronic health record
- endoplasmic reticulum stress
- hydrogen peroxide
- cell death
- signaling pathway
- data analysis
- immune response
- mass spectrometry
- cell proliferation
- pi k akt