Enantioselective hydrogenation of cyclic tetrasubstituted-olefinic dehydroamino acid derivatives.
Feng WanNan WangYuxin ZhuChuyan TangJerome P ClaverieWenjun TangPublished in: Chemical communications (Cambridge, England) (2021)
An efficient asymmetric hydrogenation of cyclic tetrasubstituted-olefinic dehydroamino acid derivatives has been achieved with a Rh-ArcPhos catalyst, affording a series of α-acylamino-β-alkyl tetrahydropyranones with two contiguous chiral centers in up to 96% ee and 1000 TON.