Antimicrobial Stewardship and Environmental Decontamination for the Control of Clostridium difficile Transmission in Healthcare Settings.
Jason BintzSuzanne LenhartCristina LanzasPublished in: Bulletin of mathematical biology (2016)
We implement an agent-based model for Clostridium difficile transmission in hospitals that accounts for several processes and individual factors including environmental and antibiotic heterogeneity in order to evaluate the efficacy of various control measures aimed at reducing environmental contamination and mitigating the effects of antibiotic use on transmission. In particular, we account for local contamination levels that contribute to the probability of colonization and we account for both the number and type of antibiotic treatments given to patients. Simulations illustrate the relative efficacy of several strategies for the reduction of nosocomial colonizations and nosocomial diseases.
Keyphrases
- clostridium difficile
- human health
- healthcare
- risk assessment
- end stage renal disease
- ejection fraction
- life cycle
- newly diagnosed
- drinking water
- chronic kidney disease
- acinetobacter baumannii
- peritoneal dialysis
- single cell
- pseudomonas aeruginosa
- molecular dynamics
- staphylococcus aureus
- social media
- climate change
- multidrug resistant
- health information