A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes.

Published in: Angewandte Chemie (International ed. in English) (2022)

After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

Keyphrases

positron emission tomography
molecular docking
anti inflammatory
computed tomography
molecular dynamics simulations
emergency department
drug induced