One-Hour Post-Load Plasma Glucose and Altered Glucometabolic Profile in Youths with Overweight or Obesity.
Procolo Di BonitoGiuliana ValerioMaria Rosaria LicenziatiDomenico CoricaMalgorzata Gabriela WasniewskaAnna Di SessaEmanuele Miraglia Del GiudiceAnita MorandiClaudio MaffeisEnza MozzilloValeria CalcaterraFrancesca FrancoGiulio MaltoniMaria Felicia FaienzaPublished in: International journal of environmental research and public health (2023)
In youths, two cut-offs (133 and 155 mg/dL) have been proposed to identify high glucose levels at the 1 h (G 60 ) mark during an oral glucose tolerance test (OGTT). We evaluated which cut-off was more closely associated with isolated impaired glucose tolerance (IGT) and cardiometabolic risk (CMR) in 1199 youth with overweight/obesity (OW/OB) and normal fasting glucose and/or HbA1c. The disposition index (DI) was available in 724 youths. The sample was divided by two cut-offs of G 60 : <133 mg/dL (n = 853) and ≥133 mg/dL (n = 346), or G 60 < 155 mg/dL (n = 1050) and ≥155 mg/dL (n = 149). Independent of the cut-off, youths with high levels of G 60 showed higher levels of G 120 , insulin resistance (IR), triglycerides to HDL ratio (TG/HDL), alanine aminotransferase (ALT), and lower insulin sensitivity (IS) and DI than youths with lower levels of G 60 . The percentage of youths showing IGT, IR, low IS, high TG/HDL ratio, high ALT, and low DI was 50% higher in the G 60 ≥ 133 mg/dL group than in the G 60 ≥ 155 mg/dL one. In youths with OW/OB and IGT, a cut-off of G 60 ≥ 133 mg/dL is more useful than G 60 ≥ 155 mg/dL to identify those at high risk of IGT and altered CMR profile.