Duodenal mucosal secretory disturbances in functional dyspepsia.

Susrutha Puthanmadhom NarayananDavid R LindenStephanie A PetersAnshuman DesaiSaatchi KuwelkerDaniel O'BrienThomas J SmyrkRondell P GrahamMadhusudan Grover Adil E Bharucha

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

Compared to controls, FD patients had greater baseline and agonist-evoked duodenal mucosal secretory responses. These findings may be explained by reduced gene expression, which would be anticipated to reduce luminal bicarbonate secretion. The upregulated miRNAs may partly explain the downregulation of these genes in FD.

Keyphrases

gene expression
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
dna methylation
cell proliferation
prognostic factors
genome wide identification