Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration.

Dibyadeep DattaIsabella PeroneDenethi WijegunawardanaFeng LiangYury M MorozovJon ArellanoAlvaro DuqueZhongcong XieChristopher H van DyckMary Kate P JoyceAmy F T Arnsten

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

These data help to explain why pT217-tau predicts degeneration in AD and how it gains access to CSF and plasma to serve as a fluid biomarker.

Keyphrases

prefrontal cortex
early stage
cerebrospinal fluid
high resolution
electronic health record
big data
sentinel lymph node
mass spectrometry
lymph node
photodynamic therapy
high frequency