Liquid biopsy from research to clinical practice: focus on non-small cell lung cancer.
Umberto MalapellePasquale PisapiaAlfredo AddeoOscar ArrietaBeatriz BellosilloAndres F CardonaMassimo CristofanilliDiego de Miguel PérezValeria DenninghoffIgnacio DuránEloísa Jantus-LewintrePier Vitale NuzzoKen O'ByrnePatrick PauwelsEdward M PickeringLuis E RaezAlessandro RussoMaria José SerranoDavid R GandaraGiancarlo TronconeChristian RolfoPublished in: Expert review of molecular diagnostics (2021)
Liquid biopsy should be considered not only as a valid alternative but as complementary to tissue-based molecular approaches. Careful attention should be paid to the optimization and standardization of all phases of liquid biopsy samples management in order to determine a significant improvement in either sensitivity or specificity, while significant reducing the number of 'false negative' or 'false positive' molecular results.