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Vitexin Inhibits Gastric Cancer Growth and Metastasis through HMGB1-mediated Inactivation of the PI3K/AKT/mTOR/HIF-1α Signaling Pathway.

Peng ZhouZi-Han ZhengTao WanJie WuChuan-Wen LiaoXue-Jun Sun
Published in: Journal of gastric cancer (2021)
Vitexin inhibited the malignant progression of GC in vitro and in vivo by suppressing HMGB1-mediated activation of PI3K/Akt/HIF-1α signaling pathway. Thus, vitexin may serve as a promising therapeutic agent for the treatment of GC.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell cycle arrest
  • cell proliferation
  • induced apoptosis
  • epithelial mesenchymal transition
  • endothelial cells
  • gas chromatography
  • high resolution