Chicoric acid ameliorates palmitate-induced sphingosine 1-phosphate signaling pathway in the PBMCs of patients with newly diagnosed type 2 diabetes.
Zahra Arab SadeghabadiKeihan Ghatreh SamaniFatemeh YaghubiRoohollah MohseniPublished in: Journal of diabetes and metabolic disorders (2022)
These data indicate that CA could be considered as a novel S1P signaling pathway inhibitor through down regulation of SPHK1 and S1PR1.
Keyphrases
- signaling pathway
- newly diagnosed
- type diabetes
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- high glucose
- electronic health record
- cardiovascular disease
- glycemic control
- mouse model
- big data
- oxidative stress
- endothelial cells
- insulin resistance
- cell proliferation
- adipose tissue
- metabolic syndrome
- data analysis
- protein kinase
- artificial intelligence