Reduced osteoclast-derived apoptotic bodies in bone marrow characterizes the pathological progression of osteoporosis.
Yutong WuHongbo AiYuhang XiPengbin YinYing QuJianzhong XuCe DouFei LuoPublished in: Cell death discovery (2023)
Osteoporosis is associated with excessive activity of osteoclasts. In bone turn over, most osteoclasts undergo apoptosis after bone resorption and produce a large number of apoptotic bodies (ABs). However, the biological function of osteoclast-derived apoptotic bodies (OC-ABs) in the progression of osteoporosis is still unknow. In our study, we identified a reduction of OC-AB quantity in the bone marrow cavity during the progression of osteoporosis, an apoptotic body-deficient MRL/lpr mice were used to study the pro-osteogenic ability of OC-ABs. Mechanistically, OC-ABs promote osteogenesis of bone mesenchymal stem cells (BMSCs) by activating the downstream mTOR pathway via RANKL-mediated reverse signaling. Moreover, systemic infusion of exogenous OC-ABs effectively delayed the bone loss in ovariectomized (OVX) mice, validated the role of OC-ABs as bone protective factor in the pathogenesis of osteoporosis. Taken together, our study elucidates the biological function of OC-ABs in the pathological progression of osteoporotic bone loss and suggests a potential therapeutic strategy to delay bone loss.
Keyphrases
- bone loss
- bone marrow
- mesenchymal stem cells
- bone mineral density
- postmenopausal women
- cell death
- anti inflammatory
- low dose
- stem cells
- umbilical cord
- type diabetes
- metabolic syndrome
- cell proliferation
- immune response
- oxidative stress
- weight loss
- skeletal muscle
- inflammatory response
- living cells
- cell cycle arrest
- endoplasmic reticulum stress
- sensitive detection
- high fat diet induced
- cell therapy