Login / Signup

CD34 negative HLA-DR negative acute myeloid leukaemia: A higher association with NPM1 and FLT3-ITD mutations.

Smeeta GajendraRitu GuptaDeepshi ThakralSanjeev Kumar GuptaGarima JainSameer BakhshiAtul SharmaRanjeet Kumar SahooLalit KumarSandeep RaiSaroj SinghAshish Datt Upadhyay
Published in: International journal of laboratory hematology (2022)
We found that the CD34 negative HLADR negative non APL AML is highly associated with NPM1 and FLT3-ITD mutation, older age at diagnosis, DIC, higher total leucocyte count, higher blast counts and normal karyotype in comparison to CD34 positive HLA-DR negative AML group. Co-occurrence of NPM1 and FLT3-ITD mutation was also exclusively seen in CD34 negative HLA-DR negative group. There was poor overall survival in CD34 positive HLA-DR negative AML than CD34 negative HLA-DR negative AML cases.
Keyphrases
  • acute myeloid leukemia
  • allogeneic hematopoietic stem cell transplantation
  • editorial comment
  • intensive care unit
  • tyrosine kinase
  • dendritic cells
  • bone marrow
  • respiratory failure
  • drug induced
  • clinical evaluation