Conditioned media from dental pulp stem cells improved diabetic polyneuropathy through anti-inflammatory, neuroprotective and angiogenic actions: Cell-free regenerative medicine for diabetic polyneuropathy.

Eriko MakinoNobuhisa NakamuraMegumi MiyabeMizuho ItoSaki KanadaMasaki HataTomokazu SaikiKazunori SangoHideki KamiyaJiro NakamuraKen MiyazawaShigemi GotoTatsuaki MatsubaraKeiko Naruse

Published in: Journal of diabetes investigation (2019)

We showed that DPSC-CM injection into hindlimb skeletal muscles has a therapeutic effect on diabetic polyneuropathy through neuroprotective, angiogenic and anti-inflammatory actions. DPSC-CM could be a novel cell-free regenerative medicine treatment for diabetic polyneuropathy.

Keyphrases

cell free
anti inflammatory
type diabetes
stem cells
wound healing
circulating tumor
cerebral ischemia
mesenchymal stem cells
brain injury
ultrasound guided
replacement therapy