Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice.

Yiqing CaiZhe YuXueping YangWeikang LuoEn HuTeng LiWenxin ZhuYang WangTao TangJie-Kun Luo

Published in: Chinese medicine (2023)

Animal experiments in combination with bioinformatics analysis confirmed that BYHWD plays a neuroprotective role in ICH by regulating Ctsb to enhance autophagy.

Keyphrases

bioinformatics analysis
signaling pathway
cell death
endoplasmic reticulum stress
cerebral ischemia
oxidative stress
brain injury
single cell
high fat diet induced
network analysis
subarachnoid hemorrhage
rna seq
metabolic syndrome
adipose tissue
type diabetes
insulin resistance
blood brain barrier