The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps.
Brendan AntiochosDaniela Trejo-ZambranoParide FenaroliAvi RosenbergAlan BaerArchit GargJungsan SohnJessica LiMichelle PetriDaniel W GoldmanChristopher MecoliLivia A Casciola-RosenAntony RosenPublished in: eLife (2022)
These studies were funded by NIH R01 DE12354 (AR), P30 AR070254, R01 GM 129342 (JS), K23AR075898 (CM), K08AR077100 (BA), the Jerome L. Greene Foundation and the Rheumatology Research Foundation. Dr. Antiochos and Dr. Mecoli are Jerome L. Greene Scholars. The Hopkins Lupus Cohort is supported by NIH grant R01 AR069572. Confocal imaging performed at the Johns Hopkins Microscopy Facility was supported by NIH Grant S10 OD016374.