Predicting Lipid-Rich Plaque Progression in Coronary Arteries Using Multimodal Imaging and Wall Shear Stress Signatures.
Giuseppe De NiscoEline M J HartmanElena TortaJoost DaemenClaudio ChiastraDiego GalloUmberto MorbiducciJolanda J WentzelPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Luminal exposure to high TSVI, solely or combined with a lipid-rich plaque phenotype, is associated with enhanced plaque progression at 1-year follow-up. Where plaque progression occurred, low TAWSS was also observed. These findings suggest TSVI, in addition to low TAWSS, as a potential biomechanical predictor for plaque progression, showing promise for clinical translation to improve patient prognosis.