Pleuroparenchymal Fibroelastosis as a Late-Onset Pulmonary Toxicity after Treatment with Anticancer Chemotherapy for High-Risk Neuroblastoma.
Satoshi YokoyamaRisa KanaiDaisuke FukaoKeigo HamahataPublished in: Case reports in pediatrics (2024)
Pleuroparenchymal fibroelastosis (PPFE) is a rare, progressive, restrictive lung disease characterized by hypercarbic respiratory failure. In pediatrics, it has been described in patients with a history of malignancy who have received a bone marrow transplant, chemotherapy, or radiotherapy. It is characterized by pleural thickening, fibrosis, subpleural elastosis, and intraalveolar collagen deposits. Survival is poor, and the only therapy is lung transplantation. Here, we report a patient who developed PPFE as a late-onset pulmonary toxicity after treatment with anticancer chemotherapy for high-risk neuroblastoma (NB).
Keyphrases
- late onset
- locally advanced
- early onset
- respiratory failure
- bone marrow
- extracorporeal membrane oxygenation
- pulmonary hypertension
- rectal cancer
- oxidative stress
- squamous cell carcinoma
- radiation therapy
- multiple sclerosis
- early stage
- case report
- acute respiratory distress syndrome
- intensive care unit
- smoking cessation