Neuronal underpinnings of cognitive impairment in bipolar disorder: A large data-driven functional magnetic resonance imaging study.
Jeff Zarp PetersenCristina VaroCecilie F SkovsenCaroline V OttHanne Lie KjærstadEduard VietaCatherine J HarmerGitte M KnudsenLars Vedel KessingJulian MacoveanuKamilla Woznica MiskowiakPublished in: Bipolar disorders (2021)
Cognitive impairment in BD seems to originate from a failure to recruit key regions in the CCN and to suppress task-irrelevant DMN activity during cognitive performance. These results highlight modulation of aberrant dorsal prefrontal and DMN activity as a putative target for pro-cognitive treatment in BD.