BMP10 reflects pre-capillary pulmonary hemodynamics: association of biomarkers and hemodynamic parameters in pulmonary hypertension.

Elisa HenningsStefanie AeschbacherMichael CoslovskyRebecca E PaladiniGian VoellminMaurin LampartAndré ZieglerChristian MüllerDavid ConenChristine S ZuernMichael KühneStefan OsswaldOtmar Pfister

Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2024)

Several biomarkers were strongly associated with mPAP, PAWP, and PVR. BMP10 was the only biomarker strongly associated with mPAP and PVR, but not with PAWP, thus reflecting the pre-capillary PH component. Measurement of BMP10 along with NT-proBNP may aid in diagnosing PH.

Keyphrases

pulmonary hypertension
mesenchymal stem cells
bone regeneration
pulmonary artery
pulmonary arterial hypertension
bone marrow