Decreased effector regulatory T cells and increased activated CD4+ T cells in premature ovarian insufficiency.

Mutsumi KobayashiAkitoshi NakashimaOsamu YoshinoMasanori YoshieAkemi UshijimaMasami ItoYosuke OnoTomoko ShimaKazuhiro KawamuraBunpei IshizukaShigeru Saito

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

This is the first report of decreased numbers of effector Treg cells and increased CD4+ CD69+ activated T cells in peripheral blood in POI, suggesting that POI is an autoimmune disease.

Keyphrases

regulatory t cells
peripheral blood
dendritic cells
induced apoptosis
cell cycle arrest
multiple sclerosis
oxidative stress
cell proliferation
type iii