High-Dimensional Mass Cytometry Reveals Emphysema-associated Changes in the Pulmonary Immune System.

Li JiaNa LiTamim R M AbdelaalNannan GuoMarieke E IJsselsteinVincent van UnenCiska LindelaufQinyue JiangYanling XiaoM Fernanda PascuttiPieter S HiemstraFrits KoningJan StolkP Padmini S J Khedoe

Published in: American journal of respiratory and critical care medicine (2024)

Using single-cell CyTOF, we characterized the alterations of the immune cell signature in alveolar tissue from patients with COPD stage III/IV emphysema versus control lung tissue. These data contribute to a better understanding of the pathogenesis of emphysema and highlight the feasibility of interrogating the immune cell signature using single-cell and IMC in human lung tissue.

Keyphrases

single cell
chronic obstructive pulmonary disease
lung function
rna seq
idiopathic pulmonary fibrosis
high throughput
pulmonary fibrosis
cystic fibrosis
machine learning
deep learning
data analysis