The Adverse Effects of Commonly Prescribed Antiseizure Medications in Adults With Newly Diagnosed Focal Epilepsy.
Sarah N BarnardZhibin Chen MBiostatAndres M KannerManisha Gupte HolmesPavel KleinBassel W Abou-KhalilBarry E GidalJacqueline A FrenchPiero Peruccanull nullPublished in: Neurology (2024)
Systematic screening for AEs in adults with newly diagnosed focal epilepsy on ASM monotherapy showed that those with comorbid psychiatric conditions report greater AEs overall, irrespective of ASM. Levetiracetam was associated with >3-fold risk of psychiatric AEs and half the risk of experiencing unsteadiness than lamotrigine. Levetiracetam had the highest proportion of discontinuations because of AEs alone, while lamotrigine had the lowest.