JAK-STAT Activity in Peripheral Blood Cells and Kidney Tissue in IgA Nephropathy.

Jianling TaoLaura MarianiSean EddyHolden MaeckerNeeraja KambhamKshama MehtaJohn HartmanWeiqi WangMatthias KretzlerRichard A Lafayette

Published in: Clinical journal of the American Society of Nephrology : CJASN (2020)

Janus kinase signal transducer and activator of transcription signaling was activated in patients with IgA nephropathy compared with controls. There were altered responses in peripheral immune cells and increased message and activated proteins in the kidney. These changes variably related to proteinuria and kidney function.

Keyphrases

peripheral blood
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
nuclear factor
cell death
signaling pathway
protein kinase
cell proliferation
inflammatory response
drug induced