Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.

Jeffery HoHung ChanYonghao LiangXiaodong LiuLin ZhangQing LiYuchen ZhangJudeng ZengFelix N UgwuIdy H T HoWei HuJohnny C W YauSunny H WongWai Tat WongLowell LingChi H ChoRichard L GalloTony GinGary TseJun YuMatthew T V ChanCzarina C H LeungWilliam Ka Kei Wu

Published in: Critical care (London, England) (2020)

Endogenous cathelicidin promotes intestinal barrier integrity accompanied by modulating the infiltration of neutrophils and macrophages in polymicrobial sepsis. Our data suggested that 1alpha, 25-dihydroxyvitamin D3 but not cholecalciferol is a potential therapeutic agent for treating sepsis.

Keyphrases

septic shock
acute kidney injury
intensive care unit
signaling pathway
electronic health record
big data