Endothelial-specific depletion of TGF-β signaling affects lymphatic function.

Kunpei FukasawaKako HanadaKei IchikawaMasanori HirashimaTakahiro TakagiSusumu ItohTesturo WatabeFumiko Itoh

Published in: Inflammation and regeneration (2021)

These data suggest that TGF-β signaling in LECs maintains the structure of lymphatic vessels and lymphatic homeostasis, in addition to promoting tumor lymphatic metastasis. Therefore, suppression of TGF-β signaling in LECs might be effective in inhibiting cancer metastasis.

Keyphrases

lymph node
transforming growth factor
signaling pathway
endothelial cells
squamous cell carcinoma
epithelial mesenchymal transition
machine learning
big data
squamous cell
artificial intelligence
data analysis