Contribution of BRCA1 5382insC mutation to triplene-gative and luminal types of breast cancer in Ukraine.

Anastasiia Samusieva Svitlana V Serga Sergiy Klymenko Lyudmila Rybchenko Bohdana Klimuk Liubov Zakhartseva Nataliia Gorovenko Olga Lobanova Zoia Rossokha Liliia Fishchuk Nataliia Levkovich Nataliia Medvedieva Olena Popova Valeriy Cheshuk Mariia Inomistova Natalia Khranovska Oksana Skachkova Yurii Michailovich Olga Ponomarova Iryna A Kozeretska

Published in: Breast cancer research and treatment (2022)

The BRCA1 c.5382 mutation rate was recorded for the first time for TNBC patients in a Ukrainian population. The results presented in this study underscore the importance of this genetic testing of mutations in patients with TNBC. Our study supports BRCA1/2 genetic testing for all women diagnosed with TNBC, regardless of the age of onset or family history of cancer and not only for women diagnosed with TNBC at <60y.o., as guidelines recommend.

Keyphrases

breast cancer risk
end stage renal disease
polycystic ovary syndrome
newly diagnosed
chronic kidney disease
squamous cell carcinoma
type diabetes
prognostic factors
pregnant women