Establishing Background Pathologic Changes of Valve Replacement Surgery in Sheep.
Jill T Schappa FaustichJohn P CarneyMatthew T LahtiBenjamin L ZhangRichard W BiancoPublished in: Cardiovascular engineering and technology (2021)
The sheep model for AVR and MVR requires invasive surgery and CPB, which are associated with background anatomic and pathologic changes, especially in cases with additional surgical cardiac interventions. These findings serve as a critical control for future evaluation and development of novel replacement valves in order to distinguish device-related safety issues from expected outcomes of the surgical procedure and normal background changes in sheep.
Keyphrases
- minimally invasive
- coronary artery bypass
- aortic valve
- neoadjuvant chemotherapy
- surgical site infection
- locally advanced
- physical activity
- mitral valve
- squamous cell carcinoma
- heart failure
- current status
- type diabetes
- aortic valve replacement
- radiation therapy
- adipose tissue
- transcatheter aortic valve replacement
- clinical evaluation