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Diffusion prepared pseudo-continuous arterial spin labeling reveals blood-brain barrier dysfunction in patients with CADASIL.

Chen LingJinyuan ZhangXingfeng ShaoLi BaiZhixin LiYunchuang SunFan LiZhaoxia WangRong XueYan ZhuoQi YangZihao ZhangDanny J J WangYun Yuan
Published in: European radiology (2023)
• DP-pCASL reveals blood-brain barrier dysfunction in patients with CADASIL. • Decreased BBB water exchange rate, an indicator of BBB dysfunction detected by DP-pCASL, was associated with MRI/clinical features of patients with CADASIL. • DP-pCASL can be used as an evaluation method to assess the severity of disease in patients with CADASIL.
Keyphrases
  • blood brain barrier
  • cerebral ischemia
  • oxidative stress
  • magnetic resonance imaging
  • single molecule
  • density functional theory
  • magnetic resonance
  • brain injury