Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice.

Karim C El KasmiAimee L AndersonMichael W DevereauxNatarajan BalasubramaniyanFrederick J SuchyDavid J OrlickyColin T ShearnRonald J Sokol

Published in: JPEN. Journal of parenteral and enteral nutrition (2021)

TNFα is a key mediator in the pathogenesis of PNAC through suppression of hepatocyte Abcb11, Abcc2, and Abcg5/8. Pharmacologic targeting of TNFα as a therapeutic strategy for PNAC thus deserves further investigation.

Keyphrases

rheumatoid arthritis
drug induced
liver injury
high fat diet induced
cancer therapy
drug delivery
insulin resistance
skeletal muscle